CPB2 polyclonal antibody

• Background:

  Carboxypeptidase B2 (CPB2) Homo sapiens Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues) . The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

• Structure Composition:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Product Name Alternative:

  CPB2; Carboxypeptidase B2; Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI

• Swiss Prot:

  Q96IY4

• Reactivity:

  Human

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human CPB2. AA range:321-370

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Dilution:

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 48 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For

• Specificity:

  TAFI Polyclonal Antibody detects endogenous levels of TAFI protein.

• Applications Notes:

  Western blot analysis of lysates from HepG2 cells, using CPB2 Antibody. The lane on the right is blocked with the synthesized peptide.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4