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JHD3B polyclonal antibody

CAT: 0384-BS65184-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS65184-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cofactor:Binds 1 Fe (2+) ion per subunit., domain:The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails., function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate., similarity:Belongs to the JHDM3 histone demethylase family., similarity:Contains 1 JmjC domain., similarity:Contains 1 JmjN domain., similarity:Contains 2 PHD-type zinc fingers., similarity:Contains 2 Tudor domains.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Product Name Alternative
KDM4B; JHDM3B; JMJD2B; KIAA0876; Lysine-specific demethylase 4B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B
Swiss Prot
O94953
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human KDM4B. AA range:351-400
Conjugation
Unconjugated
Related Pathways
Epigenetic Writers and Erasers of Histone H3
Applications
IHC-p, IF (paraffin section), ELISA
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Modification
Unmodification
Molecular Weight
/
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
JMJD2B Polyclonal Antibody detects endogenous levels of JMJD2B protein.
Applications Notes
Immunohistochemistry analysis of paraffin-embedded human brain, using JHD3B Antibody. The picture on the right is blocked with the synthesized peptide.
Host or Source
Rabbit

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