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ERRβ polyclonal antibody

CAT: 0384-GCP06-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-GCP06-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ERRβ/γ Antibody (E-1) is a high quality monoclonal ERRβ/γ antibody (also designated ERRβ/γ antibody) suitable for the detection of the ERRβ/γ protein of mouse, rat and human origin. ERRβ/γ Antibody (E-1) is available as both the non-conjugated anti-ERRβ/γ antibody form, as well as multiple conjugated forms of anti-ERRβ/γ antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Estrogen and progesterone receptors are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. Estrogen receptor-related proteins (ERRα, β and γ) are orphan nuclear receptors. Like estrogen receptors, ERRs bind specifically to EREs to activate reporter genes. ERRβ, also known as steroid hormone receptor ERR2 or estrogen receptor-like 2, is expressed during mammary gland development and is critical in embryo development. The loss of ERRβ results in severely impaired chorion formation leading to placental failure and embryonic death. ERRβ also potently represses the transcriptional activity of Nrf2. ERRγ, also known as ERR3, is abundantly expressed in fetal heart. The loss of ERRγ results in lactatemia and death within the first week of life.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Steroid hormone receptor ERR2; ERR beta-2; Estrogen receptor-like 2; Estrogen-related receptor beta; ERR-beta; Nuclear receptor subfamily 3 group B member 2; ESRRB; ERRB2; ESRL2; NR3B2
Swiss Prot
O95718
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human ERRβ.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 48 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ERRβ polyclonal antibody detects endogenous levels of ERRβ protein.
Applications Notes
Western blot (WB) analysis of ERRβ polyclonal antibody at 1:1000 dilution Lane1:MCF-7 whole cell lysate (40ug) Lane2:MCF-7 nuclear lysate (20ug)
Host or Source
Rabbit

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