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MAPKAPK-2 (T334) polyclonal antibody

CAT: 0384-AP0573-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-AP0573-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In response to cytokines, stress, and chemotactic factors, MAP kinase-activated protein kinase 2 (MAPKAPK-2) is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK. Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues (Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in an in vitro kinase assay. Phosphorylation at Thr222, Ser272, and Thr334 appears to be essential for the activity of MAPKAPK-2. Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2
Swiss Prot
P49137
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human MAPKAPK-2.
Conjugation
Unconjugated
Related Pathways
Regulation of Microtubule Dynamics, Signaling Pathways Activating p38 MAP KinaseMAPK Erk in Growth and Differentiation Pathway
Applications
WB IF
Dilution
WB: 1:5000~1:10000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95%
Modification
Unmodification
Molecular Weight
~ 45 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MAPKAPK-2 (T334) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.
Applications Notes
Western blot (WB) analysis of MAPKAPK-2 (T334) polyclonal antibody at 1:5000 dilution Lane1:PC12 whole cell lysate (40ug) Lane2:BV2 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug) Lane4:K562 whole cell lysate (40ug) Lane5:MCF-7 whole cell lysate (40ug)
Host or Source
Rabbit

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