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CD5 monoclonal antibody

CAT: 0384-MB65993-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB65993-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD5 is a type-I transmembrane protein belonging to the scavenger receptor cysteine-rich (SRCR) family, characterized by the presence of at least one SRCR domain of 90-110 amino acids. CD5 is expressed by all mature T cells, the B-1a subset of mature B cells, and some leukemic B cells. Its expression is increased in regulatory T and B cells (Tregs/Bregs) . Anergic T and B cells also have elevated CD5 expression. Elevated levels of CD5 are also found in many autoimmune disorders. CD5 is associated with the T cell receptor (TCR) and negatively modulates T cell activation and differentiation. CD5 expression on the tumor infiltrating T lymphocytes is inversely correlated with their antitumor activity. Recently, it was reported that CD5 directly binds to IL6 and can mediate downstream signaling. CD5+ B cells promote tumor growth in animal models. Reagents targeting CD5 have been actively pursued as therapeutic interventions for cancer and other conditions.
CAS Number
9007-83-4
Structure Composition
Mouse IgG. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Product Name Alternative
LEU1; T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; CD5
Swiss Prot
P06127
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within human CD5. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC (1/100 - 1/300)
Purity
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CD5 protein.
Host or Source
Mouse

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