CD81 monoclonal antibody

• Background:

  CD81 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) . Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin enriched microdomains (TEMs) where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction. CD81, like other tetraspanins, is enriched in exosomes. Many research studies demonstrate a role for CD81 in lymphocyte signaling. CD81 is also a well-characterized receptor for Hepatitis C Virus and facilitates the entry of the virus into target cells.

• Structure Composition:

  Mouse IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

• Product Name Alternative:

  TAPA1; TSPAN28; CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative monoclonal antibody 1; Tetraspanin-28; Tspan-28; CD antigen CD81

• Swiss Prot:

  P60033

• Reactivity:

  Human

• Immunogen:

  Native purified human CD81.

• Conjugation:

  Unconjugated

• Applications:

  IF, FC

• Dilution:

  IF (1/50 - 1/200)

• Purity:

  The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 25 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes human CD81

• Applications Notes:

  Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD81 Antibody, followed by anti-mouse IgG PE.

• Host or Source:

  Mouse

• CAS Number:

  9007-83-4