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CD31 monoclonal antibody

CAT: 0384-MB65771-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB65771-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.
Product Name Alternative
Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD antigen CD31
Swiss Prot
P16284
Reactivity
Human
Immunogen
Native purified human CD31.
Conjugation
Unconjugated
Applications
IF, FC
Dilution
IF (1/50 - 1/200)
Purity
The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 82 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes human CD31
Applications Notes
Flow cytometric analysis of human peripheral blood platelets using Anti-CD31 Antibody, followed by anti-mouse IgG PE.
Host or Source
Mouse

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