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CD31 polyclonal antibody

CAT: 0384-NCP0199P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0199P-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; PECAM1
Swiss Prot
P16284
Reactivity
Human
Immunogen
Recombinant protein of human CD31.
Conjugation
Unconjugated
Applications
WB IP IF
Dilution
WB: 1:5000~1:10000 IP 1:50 - 1:200 IF 1:100 - 1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 130 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD31 polyclonal antibody detects endogenous levels of CD31 protein.
Applications Notes
Western blot (WB) analysis of CD31 polyclonal antibody at 1:5000 dilution Lane1:Jurkat whole cell lysate (30ug) Lane2:THP-1 whole cell lysate (30ug) Lane3:A549 whole cell lysate (30ug)
Host or Source
Rabbit

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MBS8578670-01CD31 Polyclonal Antibody

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