ARRDC3 polyclonal antibody

• Background:

  Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550) .Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550) .May recruit NEDD4 to ADRB2 (PubMed:20559325) .

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  KIAA1376; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; TLIMP

• Swiss Prot:

  Q96B67

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ARRDC3. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, IF/ICC

• Dilution:

  WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500)

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 53 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of ARRDC3 protein.

• Applications Notes:

  Western blot analysis of ARRDC3 expression in rat liver (A), rat muscle (B) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4