ARRDC3 polyclonal antibody

• Background :

  Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550) .Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550) .May recruit NEDD4 to ADRB2 (PubMed:20559325) .

• Structure Composition :

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative :

  KIAA1376; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; TLIMP

• Swiss Prot :

  Q96B67

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ARRDC3. The exact sequence is proprietary.

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC, IF/ICC

• Dilution :

  WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500)

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 53 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  Recognizes endogenous levels of ARRDC3 protein.

• Applications Notes :

  Western blot analysis of ARRDC3 expression in rat liver (A), rat muscle (B) whole cell lysates.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4