CD155 polyclonal antibody

• Background:

  Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells. Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells. Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma. In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  Poliovirus receptor; Nectin-like protein 5 (NECL-5) ; CD155; PVR; PVS

• Swiss Prot:

  P15151

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide, corresponding to Human CD155.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:5000~1:10000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 70 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD155 polyclonal antibody detects endogenous levels of CD155 protein.

• Applications Notes:

  Western blot (WB) analysis of CD155 polyclonal antibody at 1:10000 dilution Lane1:CT-26 whole cell lysate (30ug) Lane2:HepG2 whole cell lysate (10ug) Lane3:A549 whole cell lysate (10ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4