CD125 polyclonal antibody

• Background:

  Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils .Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5.In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway .

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125

• Swiss Prot:

  Q01344

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein of human CD125.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:2000~1:5000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 60 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD125 polyclonal antibody detects endogenous levels of CD125 protein.

• Applications Notes:

  Western blot (WB) analysis of CD125 polyclonal antibody at 1:2000 dilution Lane1:EC9706 cell membrane lysate (25ug) Lane2:MCF-7 cell membrane lysate (25ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4