CD105 polyclonal antibody

CAT: 0384-NCP0171P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0171P-01Size:50 µL
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Background
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis .Required for normal structure and integrity of adult vasculature .Regulates the migration of vascular endothelial cells .Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity) .May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity) .May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors .Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors .Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Endoglin; CD105
Swiss Prot
P17813
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human CD105.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF 1:100 - 1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD105 polyclonal antibody detects endogenous levels of CD105 protein.
Applications Notes
Western blot (WB) analysis of CD105 polyclonal antibody at 1:1000 dilution Lane1:MCF-7 cell membrane lysate (20ug) Lane2:A549 cell membrane lysate (30ug)
Host or Source
Rabbit

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