ULK1 polyclonal antibody

CAT: 0384-BS91404-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS91404-01Size:50 µL
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Background
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog (ATG1; Hatg1; Unc-51-like kinase 1; ULK1; KIAA0722
Swiss Prot
O75385
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human ULK1.
Conjugation
Unconjugated
Related Pathways
PI3K AKT signaling, MTOR signaling
Applications
WB IHC
Dilution
WB:1:500-1:1,000 IHC:1:50-1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 150 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ULK1 polyclonal antibody detects endogenous levels of ULK1 protein.
Applications Notes
Western blot (WB) analysis of ULK1 polyclonal antibody at 1:500 dilution LaneA:A549 whole cell lysate (40ug) LaneB:HEK293T whole cell lysate (40ug) LaneC:AML-12 whole cell lysate (40ug) LaneD:C6 whole cell lysate (40ug) LaneE:Panc1 whole cell lysate (40ug)
Host or Source
Rabbit

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