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ADSL polyclonal antibody

CAT: 0384-BS8096-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8096-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Adenylosuccinate lyase; ASL; Adenylosuccinase; Asase; ADSL; AMPS
Swiss Prot
P30566
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human Adenylosuccinate Lyase: 185-280/484
Conjugation
Unconjugated
Applications
WB ELISA IHC IF
Dilution
WB: 1:500-1:2000 ELISA: 1:5000-1:10000 IHC: 1:100-1:500 IF: 1:100-1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ADSL polyclonal antibody detects endogenous levels of ADSL protein.
Applications Notes
Primary: Anti-Adenylosuccinate Lyase at 1/1000 dilution
Host or Source
Rabbit

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