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MDM2 monoclonal antibody

CAT: 0384-MB67065-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB67065-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2
Swiss Prot
Q00987
Reactivity
Human
Immunogen
Recombinant fusion protein of human MDM2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
ErbB HER Signaling
Applications
WB
Dilution
WB (1/1000 - 1/2000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of MDM2 protein.
Applications Notes
Western blot analysis of MDM2 expression in MCF7 (A) whole cell lysates.
Host or Source
Mouse

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