MAP2 monoclonal antibody

CAT: 0384-MB66861-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-MB66861-01Size:50 µL
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Background
Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites . Multiple MAP2 isoforms are expressed in neurons, including high molecular weight MAP2A and MAP2B , and low molecular weight MAP2C and MAP2D . Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. GSK-3 and p44/42 MAP kinase phosphorylate MAP2 at Ser136, Thr1620, and Thr1623 . Phosphorylation at Thr1620/1623 by GSK-3 inhibits MAP2 association with microtubules and microtubule stability .
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Supplied in crude ascites with 0.01% sodium azide.
Product Name Alternative
Microtubule-associated protein 2; MAP-2
Swiss Prot
P11137
Reactivity
Human
Immunogen
Recombinant fusion protein of human MAP2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/10 - 1/50)
Modification
Unmodification
Molecular Weight
~ 59 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of MAP2 protein.
Applications Notes
Western blot analysis of MAP2 expression in MCF7 (A) whole cell lysates.
Host or Source
Mouse

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