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CIITA polyclonal antibody

CAT: 0384-BS67513-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67513-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MHC class II (MHC-II) proteins play critical roles in cellular immune responses and their expression is mainly regulated by the non-DNA binding transcription factor CIITA (MHC class II transactivator) . CIITA expression is upregulated by IFN-γ and it in turn enchances MHC-II expression and represses collagen expression . CIITA has a limited number of transcriptional targets, most of which are involved in MHC-mediated antigen presentation . Mutations in the CIITA are associated with the hereditary immunodeficiency disease Bare Lymphocyte Syndrome (BLS) which is characterized by a nearly complete absence of MHC-II expression (also referred to as MHC-II deficiency) .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
MHC2TA; MHC class II transactivator; CIITA
Swiss Prot
P33076
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CIITA. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 120 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CIITA protein.
Applications Notes
Western blot analysis of CIITA expression in Beas2B (A), Jurkat (B) whole cell lysates.
Host or Source
Rabbit

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