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DLC1 polyclonal antibody

CAT: 0384-BS67463-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67463-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Loss of expression of deleted in liver cancer 1 (DLC-1) protein correlates strongly with cancerous phenotype in a large number of human tissues, such as breast, liver, colon and prostate, and generally occurs due to genomic deletion or aberrant promotor methylation. The gene encoding DLC-1 maps to human chromasome 8p22, a region presumed to harbor tumor supressor genes based on its frequent mutation in a large number of cancers. DLC-1 localizes to the cytoplasm and restored expression leads to caspase-3 mediated apoptosis, and inhibition of cell growth and invasiveness.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
ARHGAP7; KIAA1723; STARD12; Rho GTPase-activating protein 7; Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12
Swiss Prot
Q96QB1
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human DLC1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 175 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of DLC1 protein.
Applications Notes
Western blot analysis of DLC1 expression in C6 (A), CT26 (B), LOVO (C), HEK293T (D) whole cell lysates.
Host or Source
Rabbit

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