Products for Research Use Only
RegisterLogin

FRS2 polyclonal antibody

CAT: 0384-BS67452-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS67452-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Fibroblast growth factor receptor substrate 2 (FRS2, also called Suc-associated neurotrophic factor-induced tyrosine-phosphorylated target or SNT) participates in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR) . Activation of the FGFR leads to tyrosine phosphorylation of FRS2 . Two FRS2 family members have been identified, FRS2-alpha (SNT1) and FRS2-beta (SNT2), which are phosphorylated by these RTKs. Once they are phosphorylated, they recruit SH2 domain-containing proteins including Grb2 and SHP-2 , mediating downstream signaling. Tyr436 is required for efficient SHP-2 recruitment , whereas Tyr196 functions as a docking site for Grb2-Sos complexes.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
Swiss Prot
Q8WU20
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human FRS2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
MAPK Erk in Growth and Differentiation Pathway.
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of FRS2 protein.
Applications Notes
Western blot analysis of FRS2 expression in U87MG (A), H9C2 (B) whole cell lysates.
Host or Source
Rabbit

Related Products

CatalogName
BZ16309-01Phospho-FRS2 (Tyr436) polyclonal antibody
MB12034FRS2 monoclonal antibody
BS47138-01FRS2 Recombinant Rabbit mAb
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS75206-01AaaaaASPH polyclonal antibody
BS5662-01CHST1 polyclonal antibody
BS71123-01COPS7A polyclonal antibody
BS65479-01GDN Polyclonal Antibody
BS8691-01TUSC2 polyclonal antibody
BS72779-01FBLIM1 polyclonal antibody

Alternative Products

CatalogName
JOT-AP03374-01FRS2 Polyclonal Antibody
APR16029GPolyclonal FRS2 Antibody

Popular Products