ACC alpha polyclonal antibody

CAT: 0384-BS67437-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS67437-01Size:50 µL
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Background
Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA . It is the key enzyme in the biosynthesis and oxidation of fatty acids . In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while 280 kDa ACC2 (ACCβ) is the main isoform in oxidative tissues . However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues . Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC . ACC is a potential target of anti-obesity drugs.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha
Swiss Prot
Q13085
Reactivity
Human, Mouse, Rat, Bovine, Chicken, Sheep
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ACC alpha. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
AMPK Signaling Pathway, Warburg Effect.
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 280 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of ACC alpha protein.
Applications Notes
Western blot analysis of ACC alpha expression in PC12 (A), HEK293T (B), HCT116 (C) whole cell lysates.
Host or Source
Rabbit

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