DCPS polyclonal antibody

• Background:

  Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG with up to 10 nucleotide substrates (small capped oligoribonucleotides and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP. Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3 (2,2,7GpppG with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.

• Structure Composition:

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  DCPS; ARS; DCS1; HINT-5; HINT5; HSL1; HSPC015

• Swiss Prot:

  Q96C86

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein of human DCPS (NP_054745.1) .

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB,1:1000 - 1:2000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  38kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Unmodification

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4