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CD119 polyclonal antibody

CAT: 0384-NCP0255P-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-NCP0255P-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation Associates with transmembrane accessory factor IFNGR2 to form a functional receptor.Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription.STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Interferon gamma receptor 1; IFN-gamma receptor; IFN-gamma-R1; CDw119; Interferon gamma receptor alpha-chain; IFN-gamma-R-alpha; CD119
Swiss Prot
P15260
Reactivity
Human, Rat, Mouse
Immunogen
Recombinant protein of human CD119.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 45-90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD119 polyclonal antibody detects endogenous levels of CD119 protein.
Applications Notes
Western blot (WB) analysis of CD119 polyclonal antibody at 1:1000 dilution Lane1:The Liver tissue lysate of Rat (30ug) Lane2:SP2/0 cell membrane lysate (30ug) Lane3:HepG2 whole cell lysate (30ug) Lane4:MCF-7 cell membrane lysate (30ug)
Host or Source
Rabbit

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