TRPC6 polyclonal antibody

• Background :

  The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  TRP6; FSGS2

• Swiss Prot :

  Q9Y210

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TRPC6 (NP_004612.2) .

• Conjugation :

  Unconjugated

• Applications :

  WB IHC-P

• Dilution :

  WB: 1:500-1:1000 IHC-P: 1:50-1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Molecular Weight :

  ~ 106 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  TRPC6 polyclonal antibody detects endogenous levels of TRPC6 protein.

• Applications Notes :

  Western blot analysis of extracts of Mouse pancreas, using TRPC6 antibody at 1:1000 dilution.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4