ASPP2 Rabbit monoclonal antibody

• Background:

  Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  53BP2; ASPP2; p53BP2; PPP1R13A; Tp53bp2

• Swiss Prot:

  Q13625

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human ASPP2

• Conjugation:

  Unconjugated

• Applications:

  WB IHC ICC/IF

• Dilution:

  WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

• Purity:

  Affinity-chromatography

• Modification:

  Unmodified

• Molecular Weight:

  150kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  ASPP2 Antibody detects endogenous levels of total ASPP2

• Applications Notes:

  Western blot analysis of ASPP2 expression in MCF7 cell lysate.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4