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IMPDH2 Rabbit monoclonal antibody

CAT: 0384-MB66440-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66440-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inosine-5'-monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to XMP, the first and rate-limiting step of guanine nucleotide biosynthesis. The isozymes IMPDH1 and IMPDH2 are encoded by two distinct genes. Research studies show that IMPDH2 is overexpressed in glioblastoma. In glioblastoma, IMPDH2-mediated GTP biosynthesis is essential for rRNA and tRNA synthesis and the formation of enlarged and irregular nucleoli. In addition, IMPDH1 and IMPDH2 double knockout leads to significant inhibition of tumor growth in an orthotopic glioblastoma model. Furthermore, IMPDH1 and IMPDH2 expression is upregulated in small cell lung cancer cells with low expression of ASCL1 transcription factor (ASCL1Low) . Suppression of IMPDH activity inhibits ASCL1Low small cell lung cancer growth.
CAS Number
9007-83-4
Structure Composition
Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA.
Product Name Alternative
IMPD2; Inosine-5'-monophosphate dehydrogenase 2; IMP dehydrogenase 2; IMPD 2; IMPDH 2; IMPDH-II
Swiss Prot
P12268
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human IMPDH2
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC, IP
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/100), IF/ICC (1/50 - 1/100), IP (1/10 - 1/50)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IMPDH2 protein.
Applications Notes
Western blot analysis of IMPDH2 expression in NIH3T3 (A), mouse liver (B), Hela (C), A549 (D), HL60 (E), U2OS (F), C6 (G) whole cell lysates.
Host or Source
Rabbit

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