CD137 polyclonal antibody

• Background :

  TNFRSF9 is a member of the tumor necrosis factor receptor superfamily. It is also called 4-1BB or CD137. 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells. The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells. The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation. Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative :

  Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD137; TNFRSF9; CD137; ILA

• Swiss Prot :

  Q07011

• Reactivity :

  Human, Rat, Mouse

• Immunogen :

  Recombinant protein of human CD137.

• Conjugation :

  Unconjugated

• Applications :

  IF

• Dilution :

  IF: 1:100~1:500

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  CD137 polyclonal antibody detects endogenous levels of CD137 protein.

• Applications Notes :

  Immunofluorescence analysis of RAW264.7 cells using CD137 pAb at dilution of 1:200 (40x lens) .

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4