CD82 polyclonal antibody

CAT: 0384-NCP0231P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0231P-01Size:50 µL
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Background
CD82 (KAI1) belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) . CD82 does not have enzymatic activity and appears to function by regulating the trafficking of other proteins and organization of the cell membrane. CD82 was originally described as a costimulator for T cells that directly associates with CD4 and CD8, and was subsequently identified during a screen as a metastasis suppressor in prostate cancer. CD82 has since been found to act as a metastasis suppressor in a variety of cancers, and its downregulation is associated with poor prognosis in research studies. CD82 suppresses metastasis through multiple mechanisms including inhibition of cell motility and invasion by modulating c-Met and the urokinase plasminogen activator surface receptor (uPAR), as well as promotion of homotypic cell-cell adhesion by stabilizing interactions between E-cadherin and β-catenin.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
CD82 antigen; C33 antigen; C33 antigen; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27 (Tspan-27) ; CD82
Swiss Prot
P27701
Reactivity
Human, Rat, Mouse
Immunogen
Recombinant protein of human CD82.
Conjugation
Unconjugated
Applications
IF
Dilution
IF: 1:200~1:800
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD82 polyclonal antibody detects endogenous levels of CD82 protein.
Applications Notes
Immunofluorescence analysis of Hela cells using CD82 pAb at dilution of 1:400 (40x lens) .
Host or Source
Rabbit

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