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AXL polyclonal antibody

CAT: 0384-BS61370-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61370-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor. Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB. A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Tyrosine-protein kinase receptor UFO; AXL oncogene; AXL; UFO
Swiss Prot
P30530
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AXL.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB,1:500 - 1:2000|IHC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AXL polyclonal antibody detects endogenous levels of AXL protein.
Applications Notes
Western blot analysis of AXL expression in PC3 (A), HEK293T (B), U87MG (C), SKOVCAR3 (D), C6 (E), CT26 (F) whole cell lysates.
Host or Source
Rabbit

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