FXR2 (E576) polyclonal antibody

• Background:

  The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box) . FMR1 can also interact with two fragile X syndrome related factors, FXR1 and FXR2, and these proteins form heterodimers through their N-terminal coilcoiled domains. FMR1 localizes to both the nucleus and the cytoplasm, and since it contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleo-cytoplasmic transport of mRNAs.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Fragile X mental retardation syndrome-related protein 2; FMR1L2; FXR2

• Swiss Prot:

  P51116

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to amino acids 550-600 of Human FXR2.

• Conjugation:

  Unconjugated

• Applications:

  WB IHC IF IP

• Dilution:

  WB: 1:500~1:1000 IHC/IF: 1:50~1:200 IP: 1:10~1:100

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 74 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  FXR2 (E576) polyclonal antibody detects endogenous levels of FXR2 protein.

• Applications Notes:

  Western blot (WB) analysis of FXR2 (E576) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:K562 whole cell lysate (40ug) Lane3:H9C2 whole cell lysate (40ug) Lane4:MEF whole cell lysate (40ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4