SHP-2 (E574) polyclonal antibody

CAT: 0384-BS1705-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS1705-01Size:50 µL
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Background
Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3; PTPN11; PTP2C; SHPTP2
Swiss Prot
Q06124
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 550-600 of Human SHP-2.
Conjugation
Unconjugated
Related Pathways
Immune Cell Signaling, Insulin &Glucose Signaling, B cell receptor signaling
Applications
WB IHC IP
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SHP-2 (E574) polyclonal antibody detects endogenous levels of SHP-2 protein.
Applications Notes
Western blot (WB) analysis of SHP-2 (E574) polyclonal antibody at 1:500 dilution Lane1:H9C2 whole cell lysate (40ug) Lane2:SP2/0 whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:K562 whole cell lysate (40ug)
Host or Source
Rabbit

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