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INSL3 polyclonal antibody

CAT: 0384-BS7819-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS7819-01Size:50 µL
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Background
Insulin-like factor 3 (INSL3), also designated Leydig insulin-like peptide (Ley IL) and Relaxin-like factor (RLF), is a peptide hormone in the Relaxin family which is secreted from the testicular Leydig cells and ovarian theca interna cells. INSL3 is involved in gonadal and other physiological processes. Structurally similar to Relaxin and insulin, INSL3 differs from the two in that it signals through a G protein-coupled receptor, LGR8. INSL3/LGR8 signaling is involved in gubernaculum development and transabdominal testicular descent during development. Abnormal INSL3 production or action by the fetal testis causes cryptorchidism, a developmental defect of the urogenital tract in human males wherein the testis do not descend into the scrotum during embryonic development. Infertility and the development of germ-cell tumors are two potential risks for individuals with cryptorchidism.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
INSL 3; INSL-3; INSL3_HUMAN; Insulin like 3; Insulin-like 3 A chain; Ley IL; Ley-I-L; Leydig insulin like peptide; Leydig insulin-like peptide; Relaxin like factor; Relaxin-like factor; RLF; RLNL
Swiss Prot
P51460
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 ofhuman INSL3 (NP_005534.2) .
Conjugation
Unconjugated
Applications
IHC-P IF/ICC ELISA
Dilution
IHC-P 1:50 - 1:100 IF/ICC 1:50 - 1:100 ELISA 1:5000 - 1:10000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 15 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
INSL3 polyclonal antibody detects endogenous levels of INSL3 protein.
Applications Notes
Immunohistochemistry analysis of paraffinembedded Human prostate using INSL3 pAb at dilution of 1:100 (40xlens) .
Host or Source
Rabbit

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