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Carprofen-13C, d3

CAT: 0804-HY-B1227S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1227S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carprofen-13C, d3 is the deuterium and 13C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].
CAS Number
2012598-34-2
UNSPSC
12352005
Target
Autophagy; COX; Endogenous Metabolite; FAAH
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C2NC3=CC(C([13C]([2H])([2H])[2H])C(O)=O)=CC=C3C2=C1
Molecular Formula
C14 13CH9D3ClNO2
Molecular Weight
277.73
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Favia AD, et al. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25;55 (20) :8807-26.|[3]Waldherr K, et al. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res. 2012 Nov73 (11) :1752-8.|[4]Sessions JK, et al. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res. 2005 May66 (5) :812-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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