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Atropine (hydrobromide)

CAT: 0804-HY-B1205BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1205BSize:1 Each
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Description
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4].
CAS Number
6415-90-3
Product Name Alternative
Tropine tropate (hydrobromide) ; DL-Hyoscyamine (hydrobromide)
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/atropine-hydrobromide.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.Br
Molecular Formula
C17H24BrNO3
Molecular Weight
370.28
References & Citations
[1]McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33 (3) :373-8.|[2]Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33 (2) :441-57.|[3]Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59 (7) :2778-2791.|[4]Walch L, et, al. Evidence for a M (1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130 (1) :73-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR4

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