Atropine (hydrobromide)

• Description :

  Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4].

• CAS Number :

  [6415-90-3]

• Product Name Alternative :

  Tropine tropate (hydrobromide) ; DL-Hyoscyamine (hydrobromide)

• UNSPSC :

  12352005

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/atropine-hydrobromide.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.Br

• Molecular Formula :

  C17H24BrNO3

• Molecular Weight :

  370.28

• References & Citations :

  [1]McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33 (3) :373-8.|[2]Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33 (2) :441-57.|[3]Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59 (7) :2778-2791.|[4]Walch L, et, al. Evidence for a M (1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130 (1) :73-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  MAChR4