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Clindamycin phosphate (hydrochloride)

CAT: 0804-HY-B1064ASize: 1 EachDry Ice: NoHazardous: No
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Description
Clindamycin phosphate (Clindamycin 2-phosphate) hydrochloride is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate hydrochloride is the proagent of Clindamycin with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate hydrochloride can be used for researching acne and bacterial vaginosis[1][2][3].
CAS Number
64023-51-4
Product Name Alternative
Clindamycin 2-phosphate (hydrochloride) ; U-28508 (hydrochloride)
UNSPSC
12352005
Target
Antibiotic; Bacterial; Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/clindamycin-phosphate-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCC[C@H]1CN(C)[C@H](C(N[C@@]([H])([C@@]2([H])O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O)[C@@H](Cl)C)=O)C1.[H]Cl
Molecular Formula
C18H35Cl2N2O8PS
Molecular Weight
541.42
References & Citations
[1]Li H, et al. Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system. Eur J Clin Pharmacol. 2017 Feb;73 (2) :251-253.|[2]Hayashi N, et al. Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed-dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator-blind, parallel-group study. J Dermatol. 2018 Aug;45 (8) :951-962.|[3]A. Dupre, et al. Proof of concept study of a novel bioadhesive clindamycin phosphate 2% vaginal gel to treat bacterial vaginosis. Clin. Exp. Obstet. Gynecol. 2020, 47 (4), 516–518
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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