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Clindamycin (hydrochloride)

CAT: 0804-HY-B0408A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0408A-01Size:100 mg
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Description
Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal.
CAS Number
21462-39-5
UNSPSC
12352005
Hazard Statement
H317, H319, H362
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/clindamycin-hydrochloride.html
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL
Smiles
C[C@H](Cl)[C@@]([C@@]([C@@H]([C@H](O)[C@H]1O)O)([H])O[C@@H]1SC)([H])NC([C@@H]2C[C@@H](CCC)CN2C)=O.Cl
Molecular Formula
C18H34Cl2N2O5S
Molecular Weight
461.44
Precautions
H317, H319, H362
References & Citations
[1]Batzias GC, et al. Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs. Vet J. 2005 Nov;170 (3) :339-45.|[2]Warrick JM, et al. Effect of clindamycin hydrochloride on oral malodor, plaque, calculus, and gingivitis in dogs with periodontitis. Vet Ther. 2000 Winter;1 (1) :5-16.|[3]Nielsen D, et al. Effects of treatment with clindamycin hydrochloride on progression of canine periodontal disease after ultrasonic scaling. Vet Ther. 2000 Summer;1 (3) :150-8.|[4]Bloom PB, et al. Efficacy of once-daily clindamycin hydrochloride in the treatment of superficial bacterial pyoderma in dogs. J Am Anim Hosp Assoc. 2001 Nov-Dec;37 (6) :537-42.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
BioRxiv. 2024 Jan 18.|bioRxiv. 2024 May 10.|ACS Environ Au. 2025 Aug 8.|ACS Omega. 2022 Mar 3;7 (10) :9004-9014.|Acta Pharm Sin B. 2021 Sep;11 (9) :2850-2858.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Dermatol Clin. 2024 September 12.|Diagn Microbiol Infect Dis. 2025 Nov 4;114 (2) :117181.|EBioMedicine. 2022 Apr;78:103943.|Future Microbiol. 2025 Oct 13:1-10.|Microbiol Spectr. 2025 Oct 15:e0122125.|Water Res. 2023 Jul 15:240:120110.|EBioMedicine. 2022 Apr;78:103943.|Tissue Cell. 2025 Jan 25:93:102759.

Chemical Information

Clindamycin Hydrochloride

Clindamycin hydrochloride is a S-glycosyl compound.

CAS Number21462-39-5
PubChem CID16051951
IUPAC Name(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
Molecular FormulaC18H34Cl2N2O5S
Molecular Weight461.4
Topological Polar Surface Area128
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity502
SMILES
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.Cl
InChI
InChI=1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
InChIKey
AUODDLQVRAJAJM-XJQDNNTCSA-N
Chemical Structure
2D Structure
2D structure of Clindamycin Hydrochloride
CAS: 21462-39-5
CID: 16051951
Formula: C18H34Cl2N2O5S
MW: 461.4
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight461.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass460.1565488
Monoisotopic Mass460.1565488
Topological Polar Surface Area128 Ų
Heavy Atom Count28
Formal Charge0
Complexity502
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes