Propiconazole-d7

• Description:

  Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 μM, respectively) . Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively) . Propiconazole increases production of reactive oxygen species (ROS) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301-H312-H330-H410

• Target:

  Fungal; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Solubility:

  10 mM in DMSO

• Smiles:

  C(C1(OC(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])CO1)C2=C(Cl)C=C(Cl)C=C2)N3C=NC=N3

• Molecular Formula:

  C15H10D7Cl2N3O2

• Molecular Weight:

  349.26

• Precautions:

  P264-P270-P330-P405-P501

• References & Citations:

  [1]Teng M, et al. Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (Danio rerio) . J Agric Food Chem. 2019;67 (16) :4623-4631.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1246818-14-3]