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Dimethomorph-d8

CAT: 0804-HY-B0846S-01Size: 2.5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0846S-01Size:2.5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dimethomorph-d8 is the deuterium labeled Dimethomorph[1]. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM[2][3][4].
CAS Number
[1346606-71-0]
UNSPSC
12352005
Target
Androgen Receptor; Fungal; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
O=C(N1C([2H])([2H])C([2H])([2H])OC([2H])([2H])C1([2H])[2H])/C=C(C2=CC=C(C=C2)Cl)\C3=CC(OC)=C(C=C3)OC
Molecular Formula
C21H14D8ClNO4
Molecular Weight
395.91
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]M E Matheron, et al. Impact of Azoxystrobin, Dimethomorph, Fluazinam, Fosetyl-Al, and Metalaxyl on Growth, Sporulation, and Zoospore Cyst Germination of Three Phytophthora spp. Plant Dis. 2000 Apr;84 (4) :454-458.|[3]Frances Orton, et al. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect. 2011 Jun119 (6) :794-800.|[4]Yigal Cohen, , et al. Differential Activity of Carboxylic Acid Amide Fungicides Against Various Developmental Stages of Phytophthora infestans. Phytopathology. 2007 Oct97 (10) :1274-83.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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