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Pyridaben-d13

CAT: 0804-HY-B0817SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0817SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyridaben-d13 is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria) . Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].
CAS Number
2468638-05-1
UNSPSC
12352005
Target
Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(C([2H])=C1[2H])=C([2H])C([2H])=C1CSC2=C(C(N(N=C2)C(C)(C)C)=O)Cl
Molecular Formula
C19H12D13ClN2OS
Molecular Weight
378.01
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Gomez C, et al. Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. |[3]Namin HH, et al. Resistance to pyridaben in Canadian greenhouse populations of two-spotted spider mites, Tetranychus urticae (Koch) . Pestic Biochem Physiol. 2020 Nov170:104677.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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