AZ7550-d5

• Description:

  AZ7550-d5 is the deuterium labeled AZ7550? (HY-B0794) . AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of?IGF1R?with an?IC50?of 1.6 μM[1][2].

• UNSPSC:

  12352005

• Target:

  Drug Metabolite; EGFR; IGF-1R

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC(NC2=NC=CC(C3=CN(C([2H])([2H])[2H])C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)/C=C([2H])\[2H]

• Molecular Formula:

  C27H26D5N7O2

• Molecular Weight:

  490.61

• References & Citations:

  [1]Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64 (2) :925-937. |[2]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [2719690-99-8]