Spironolactone-d3

• Description:

  Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

• Product Name Alternative:

  SC9420-d3

• UNSPSC:

  12352005

• Target:

  Androgen Receptor; Autophagy; Isotope-Labeled Compounds; Mineralocorticoid Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease; Cancer

• Purity:

  99.82

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming)

• Smiles:

  C[C@@]12[C@@]3(OC(CC3)=O)CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H]4SC(C([2H])([2H])[2H])=O)=CC(CC5)=O)C)([H])CC2

• Molecular Formula:

  C24H29D3O4S

• Molecular Weight:

  419.59

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kim GK, et al. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience. J Clin Aesthet Dermatol. 2012;5 (3) :37-50.|[3]Fagart J, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010;285 (39) :29932-29940.|[4]Dong D, et al. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol. 2019;51 (4) :755-764.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported