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Spironolactone-d7

CAT: 0804-HY-B0561S-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0561S-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spironolactone-d7 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].
Product Name Alternative
SC9420-d7
UNSPSC
12352005
Target
Androgen Receptor; Autophagy; Calcium Channel; Isotope-Labeled Compounds; Mineralocorticoid Receptor
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Cancer
Purity
99.96
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@]3(OC(C([2H])([2H])C3)=O)CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C([2H])[C@@]4([2H])SC(C)=O)=C([2H])C(C([2H])([2H])C5)=O)C)([H])CC2
Molecular Formula
C24H25D7O4S
Molecular Weight
423.62
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kim GK, et al. Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience. J Clin Aesthet Dermatol. 2012;5 (3) :37-50.|[3]Fagart J, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010;285 (39) :29932-29940.|[4]Dong D, et al. Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol. 2019;51 (4) :755-764.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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