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Idoxuridine

CAT: 0804-HY-B0307-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0307-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1]. Idoxuridine shows anti-orthopoxvirus activity.
CAS Number
54-42-2
Product Name Alternative
5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H341, H361
Target
Orthopoxvirus; Phosphatase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Idoxuridine.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(I)C1=O
Molecular Formula
C9H11IN2O5
Molecular Weight
354.10
Precautions
H315, H319, H335, H341, H361
References & Citations
[1]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[2]D E Griswold, et al. Stimulation of hemolysin plaque-forming cells by idoxuridine. Cancer Res. 1975 Jan;35 (1) :88-92.|[3]Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HSV-1

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