Pyrazinamide-d3
CAT:
804-HY-B0271S
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pyrazinamide-d3
- CAS Number: 1432059-16-9
- UNSPSC Description: Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].
- Target Antigen: Antibiotic; Autophagy; Bacterial; Isotope-Labeled Compounds
- Type: Isotope-Labeled Compounds
- Related Pathways: Anti-infection;Autophagy;Others
- Applications: COVID-19-immunoregulation
- Field of Research: Infection
- Purity: 99.84
- Solubility: 10 mM in DMSO
- Smiles: NC(C1=NC([2H])=C([2H])N=C1[2H])=O
- Molecular Weight: 126.13
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181(7):2044-9.|[3]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2(4):MGM2-0023-2013.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported