Pyrazinamide-d3

CAT: 0804-HY-B0271SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0271SSize:1 mg
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Description
Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].
CAS Number
[1432059-16-9]
Product Name Alternative
Pyrazinecarboxamide-d3; Pyrazinoic acid amide-d3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Antibiotic; Autophagy; Bacterial; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.84
Solubility
10 mM in DMSO
Smiles
NC(C1=NC([2H])=C([2H])N=C1[2H])=O
Molecular Formula
C5H2D3N3O
Molecular Weight
126.13
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181 (7) :2044-9.|[3]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2 (4) :MGM2-0023-2013.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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