Pyrazinamide

CAT: 0804-HY-B0271-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0271-01Size:500 mg
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Description
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
CAS Number
[98-96-4]
Product Name Alternative
Pyrazinecarboxamide; Pyrazinoic acid amide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Autophagy; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pyrazinamide.html
Purity
99.97
Solubility
DMSO : ≥ 50 mg/mL|H2O : 6.67 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CN=C1)N
Molecular Formula
C5H5N3O
Molecular Weight
123.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181 (7) :2044-9.|[2]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2 (4) :MGM2-0023-2013.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched

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