Pyrazinamide

• Description :

  Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

• Product Name Alternative :

  Pyrazinecarboxamide; Pyrazinoic acid amide

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Antibiotic; Autophagy; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Autophagy

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/pyrazinamide.html

• Purity :

  99.97

• Solubility :

  DMSO : ≥ 50 mg/mL|H2O : 6.67 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=NC=CN=C1)N

• Molecular Formula :

  C5H5N3O

• Molecular Weight :

  123.11

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181 (7) :2044-9.|[2]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2 (4) :MGM2-0023-2013.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [98-96-4]