Pyrazinamide

• UNSPSC Description:

  Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

• Target Antigen:

  Antibiotic; Autophagy; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Autophagy

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/pyrazinamide.html

• Purity:

  99.97

• Solubility:

  DMSO : ≥ 50 mg/mL|H2O : 6.67 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=NC=CN=C1)N

• Molecular Weight:

  123.11

• References & Citations:

  [1]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181(7):2044-9.|[2]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2(4):MGM2-0023-2013.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Clinical Information:

  Launched

• CAS Number:

  98-96-4