Methylprednisolone-d2

• Description:

  Methylprednisolone-d2 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3][4].

• Product Name Alternative:

  U 7532-d2

• UNSPSC:

  12352211

• Target:

  Autophagy; Glucocorticoid Receptor; SARS-CoV

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Autophagy; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Others

• Purity:

  99.11

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C=C[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@@](O)(C(C([2H])([2H])O)=O)CC[C@@]4([H])[C@]3([H])C[C@H](C)C2=C1

• Molecular Formula:

  C22H28D2O5

• Molecular Weight:

  376.48

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322 (20) : p. 1405-11.|[3]Strupp, M., et al., Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med, 2004. 351 (4) : p. 354-61.|[4]Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16 (13) :2382-2391.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported