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Methylprednisolone

CAT: 0804-HY-B0260-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0260-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
CAS Number
83-43-2
Product Name Alternative
U 7532
UNSPSC
12352211
Hazard Statement
H360, H373
Target
Autophagy; Bacterial; Glucocorticoid Receptor; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/methylprednisolone.html
Purity
99.78
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C=C[C@]2(C)[C@@]3([H])[C@@H](O)C[C@]4(C)[C@@](O)(C(CO)=O)CC[C@@]4([H])[C@]3([H])C[C@H](C)C2=C1
Molecular Formula
C22H30O5
Molecular Weight
374.47
Precautions
H360, H373
References & Citations
[1]Strupp, M., et al., Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med, 2004. 351 (4) : p. 354-61.|[2]Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322 (20) : p. 1405-11.|[3]Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16 (13) :2382-2391.|[4]Fan Y, et al. Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis. Bone Res. 2025 Jan 26;13 (1) :18.|[5]Yu R, et al. Physiologically Based Pharmacokinetic Modeling: The Reversible Metabolism and Tissue-Specific Partitioning of Methylprednisolone and Methylprednisone in Rats. Drug Metab Dispos. 2024 Jun 17;52 (7) :662-672.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

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A4233-1000Methylprednisolone
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