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Methylprednisolone-d7

CAT: 0804-HY-B0260S3Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0260S3Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylprednisolone-d7 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
Product Name Alternative
U 7532-d7
UNSPSC
12352211
Target
Autophagy; Glucocorticoid Receptor; SARS-CoV
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Endocrinology; Inflammation/Immunology
Purity
99.73
Solubility
10 mM in DMSO|DMSO : 125mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.1mg/mL (ultrasonic)
Smiles
O=C1C([2H])=C[C@@]2([C@]3([C@]([2H])(C([2H])([C@@]4([C@@](C(CO)=O)(CC[C@]4([C@@]3(C[C@@]([2H])(C2=C1[2H])C)[H])[H])O)C)[2H])O)[2H])C
Molecular Formula
C22H23D7O5
Molecular Weight
381.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322 (20) : p. 1405-11.|[3]Strupp, M., et al., Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med, 2004. 351 (4) : p. 354-61.|[4]Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16 (13) :2382-2391.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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