Erythromycin-d6

• Description :

  Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1].

• CAS Number :

  [959119-25-6]

• UNSPSC :

  12352005

• Target :

  Antibiotic; Bacterial

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Solubility :

  10 mM in DMSO

• Smiles :

  O([C@@H]1[C@@H](C)[C@H](O[C@H]2C[C@](OC)(C)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)O)[C@H]3[C@H](O)[C@@H](N(C([2H])([2H])[2H])C([2H])([2H])[2H])C[C@@H](C)O3

• Molecular Formula :

  C37H61D6NO13

• Molecular Weight :

  739.96

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66 (1) :79-89.|[3]Nakornchai S, et al. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006 Dec;100 (3) :185-91. Epub 2006 Nov 28.|[4]K Hamada, et al. Antitumor Effect of Erythromycin in Mice. Chemotherapy

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  Macrolide