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Erythromycin (aspartate)

CAT: 0804-HY-B0220CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0220CSize:1 Each
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Description
Erythromycin aspartate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin aspartate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin aspartate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
CAS Number
30010-41-4
UNSPSC
12352005
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/erythromycin-aspartate.html
Solubility
10 mM in DMSO
Smiles
C[C@@H]([C@@H]([C@H](C(O[C@@H]([C@@](O)1C)CC)=O)C)O[C@H](O[C@H]2C)C[C@](C)([C@H]2O)OC)[C@H]([C@](O)(C[C@H](C([C@@H]([C@H]1O)C)=O)C)C)O[C@H](O[C@@H]3C)[C@@H]([C@H](C3)N(C)C)O.OC(C[C@H](N)C(O)=O)=O
Molecular Formula
C41H74N2O17
Molecular Weight
867.03
References & Citations
[1]Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66 (1) :79-89.|[2]Nakornchai S, et al. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006 Dec. 100 (3) :185-91.|[3]Hamada K, et al. Antitumor effect of erythromycin in mice. Chemotherapy. 1995 Jan-Feb. 41 (1) :59-69. |[4]Katayama Y, et al. Neuroprotective effects of erythromycin on cerebral ischemia reperfusion-injury and cell viability after oxygen-glucose deprivation in cultured neuronal cells. Brain Res. 2014 Nov 7. 1588:159-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Macrolide

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