Erythromycin estolate

CAT: 0804-HY-N7121-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N7121-01Size:50 mg
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Description
Erythromycin estolate is the Erythromycin (HY-B0220) derivative[1], is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin estolate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin estolate toxicity is related to its inhibitory effect on bile acid transport[2].
CAS Number
[3521-62-8]
UNSPSC
12352005
Hazard Statement
H302, H317, H334
Target
Aminotransferases (Transaminases) ; Antibiotic; Bacterial; Dengue Virus; Flavivirus
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/erythromycin-estolate.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCOS(=O)(O)=O.CCC(O[C@H]([C@H](C[C@@H](C)O1)N(C)C)[C@]1([H])O[C@@H]2[C@H]([C@@H]([C@H](C(O[C@@H]([C@@](C)(O)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)CC)=O)C)O[C@@]3([H])C[C@](C)([C@@H](O)[C@H](C)O3)OC)C)=O
Molecular Formula
C52H97NO18S
Molecular Weight
1056.39
Precautions
H302, H317, H334
References & Citations
[1]Lu X, et al. Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat. Food Chem Toxicol. 2014 Mar;65:343-55.|[2]Wang X, et al., Erythromycin Estolate Is a Potent Inhibitor Against HCoV-OC43 by Directly Inactivating the Virus Particle. Front Cell Infect Microbiol. 2022 Jul 7;12:905248.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched

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